Author

Mart Ustav

Icosagen (Estonia)ORCID 0000-0002-7804-3989Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Adnan SljokaiD· 1 shared Alice ColyeriD· 1 shared Cristina LentoiD· 1 shared Derek J. WilsoniD· 1 shared Esther WolfiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperBiochemistry

Adnan SljokaORCID

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1 paper

Recent·Most cited

Allostery links hACE2 binding, pan-variant neutralisation and helical extension in the SARS-CoV-2 Spike protein

Alice Colyer, Esther Wolf, Cristina Lento, Mart Ustav, Adnan Sljoka, Derek J. Wilson

This paper shows that the antibody ICO-hu104 neutralizes SARS-CoV-2 by causing allosteric changes in the HR1 domain, leading to destabilization of helices and impairing viral fusion.

bioRxiv · Jan 28, 2025 · PreprintBiochemistry