Author

Craig J. Bierle

University of MinnesotaORCID 0000-0002-7890-7409Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:human· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Jason S. HatfieldiD· 2 shared Mark R. SchleissiD· 2 shared Micah D. GearhartiD· 2 shared Priyanka ChauhaniD· 2 shared Terry K. MorganiD· 2 shared Tyler B. RollmaniD· 2 shared Zachary W. BerkebileiD· 2 shared Adam HermaniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

Jason S. HatfieldORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pichinde virus models intrauterine infection by hemorrhagic fever-causing arenaviruses

Craig J. Bierle, Hannah L. Murphy, Jason S. Hatfield, Qinfeng Huang, Tyler B. Rollman, Priyanka Chauhan, Brigitte H. Flannery, Sarah A. Wernimont, Terry K. Morgan, Micah D. Gearhart, Yuying Liang, Hinh Ly

This study uses Pichinde virus to model arenavirus infection during pregnancy, showing placental infection and fetal demise while highlighting antiviral responses.

bioRxiv · Sep 22, 2026 · PreprintMicrobiology

Spatial Transcriptomics Reveals that the Local Immune Response to Placental Guinea Pig Cytomegalovirus Infection is Driven by Chemokine Signaling

Zachary W. Berkebile, Colleen L. Forster, Emma Stanley, Fernanda M. Rodriguez, Adam Herman, Micah D. Gearhart, Craig J. Bierle

This study uses spatial transcriptomics to show that GPCMV infection disrupts placental function by altering chemokine signaling and antiviral defense in specific regions.

bioRxiv · Aug 1, 2025 · PreprintImmunology

Replication-Deficient Whole-Virus Vaccines Against Cytomegalovirus Induce Protective Immunity in a Guinea Pig Congenital Infection Model

Mark R. Schleiss, Claudia Fernández-Alarcón, Craig J. Bierle, Adam P. Geballe, Alexey J Badillo-Guzman, Christine E Tanna, Kanokpan Tsriwong, Mark Blackstad, Jian Ben Wang, Michael A. McVoy

This study evaluates two replication-deficient whole-virus vaccines against GPCMV in a guinea pig model, showing they are attenuated and provide protective immunity against maternal viremia and congenital infection.

Journal of Virology · Jun 11, 2025Peer-reviewedImmunology

CD4+ but not CD8+ T cells are required for protection against severe guinea pig cytomegalovirus infections

Tyler B. Rollman, Zachary W. Berkebile, Dustin Hicks, Jason S. Hatfield, Priyanka Chauhan, Marco Pravetoni, Mark R. Schleiss, Gregg N. Milligan, Terry K. Morgan, Craig J. Bierle

This study shows CD4+ T cells are critical for preventing severe congenital cytomegalovirus infection in guinea pigs, while CD8+ T cell depletion increases placental viral load without affecting disease severity.

PLoS Pathogens · Nov 4, 2024Peer-reviewedImmunology