Author

Joana E. Aggrey-Fynn

Fred Hutch Cancer CenterORCID 0000-0002-7901-8128Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Adrianne Wallace-PovirkiD· 1 shared Aidan SchutteriD· 1 shared Alexander E. Orellana· 1 shared Amro AbdelrahmaniD· 1 shared Ashish Rajput· 1 shared Camilla Rydberg MillrudiD· 1 shared Débora Barbosa Vendramini Costa· 1 shared Dominik SauliD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Adrianne Wallace-PovirkORCID

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2 papers

Recent·Most cited

HMGA2 Expression in Pancreatic Ductal Adenocarcinoma Controls Tumor Microenvironment and Immunosuppression via IL1α

Naomi Yamamoto, Stephanie Dobersch, Tess M. Robertson, Jae Hyung Sim, Adrianne Wallace-Povirk, Nayvin W. Chew, Alexander E. Orellana, Joana E. Aggrey-Fynn, Liberalis Debraj Boila, Aidan Schutter, Ian M. Loveless, Gun Ho Jang, Shayan Avanessian, Gregory Lawrence Beatty, Suni R Hingorani, , Sita Kugel

This study shows HMGA2 in PDAC drives immunosuppressive TME by upregulating IL1α, which promotes CAFs and reduces CD8+ T cells, and blocking IL1 improves tumor control with KRAS inhibitors.

bioRxiv · Oct 6, 2026 · PreprintCancer Biology

Epigenetic Context Defines the Transcriptional Activity of Canonical and Noncanonical NF-κB Signaling in Pancreatic Cancer

Joana E. Aggrey-Fynn, Joshua Busch, Dominik Saul, Ashish Rajput, Kerstin Willecke, Meghana Manjunath, Nicole Klimt, Kothai Rajendran, Nadine Schacherer, Wanwan Ge, Julia Thiel, Amro Abdelrahman, Mark Joseph Truty, Meng Dong, Steven A. Johnsen

This study identifies TNF and TWEAK as activators of canonical and noncanonical NF-κB signaling in PDAC, revealing distinct epigenetic dependencies of RELA and RELB.

Cell Death Discovery · Mar 17, 2026Peer-reviewedCancer Biology