Ian M. Loveless

This study shows HMGA2 in PDAC drives immunosuppressive TME by upregulating IL1α, which promotes CAFs and reduces CD8+ T cells, and blocking IL1 improves tumor control with KRAS inhibitors.

The paper identifies cell type-specific gene expression and immune cell associations in keloid tissue using bulk RNA-Seq and single sample gene set enrichment analysis.

The paper compares primary and liver PDAC lesions using single-cell transcriptomics to identify MET as a target in pancreatic cancer metastasis.

The paper identifies CpG sites and pathways associated with gestational age and epigenetic age acceleration, and links perinatal exposures to these epigenetic changes.

This study identifies miR-126-3p as a biomarker for knee osteoarthritis, showing elevated levels in patients and reduced disease severity with mimic treatment.

This study identifies ROR2 as a regulator of cellular plasticity in pancreatic neoplasia, showing it promotes an aggressive PDAC phenotype and resistance to KRAS inhibitors.

HS-OmicsDB aggregates bulk and single-cell RNA sequencing data from untreated HS patients to profile gene expression in specific tissue types and map cell-specific gene expression in HS lesions.