Shawna Marie Hubert

A novel Bayesian model for assessing intratumor heterogeneity of tumor infiltrating leukocytes with multi-region gene expression sequencing

The paper introduces ICeITH, a Bayesian model to assess intratumor heterogeneity of tumor-infiltrating leukocytes using multi-region gene expression data, showing improved accuracy over existing methods.

Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features

The paper investigates how anti-cancer immunity evolves from preneoplasia to invasive lung adenocarcinomas, identifying changes in immune response and molecular features that may facilitate immune evasion.

Conservation of glutathione S-transferase mRNA and protein sequences similar to human and horse Alpha class GST A3-3 across dog, goat, and opossum species

The paper identifies and characterizes GSTA3 mRNA and protein sequences in dog, goat, and opossum, showing high conservation with human and horse GSTA3 and suggesting differences in enzymatic activity.

Tumor cell total mRNA expression shapes the molecular and clinical phenotype of cancer

The paper quantifies tumor-specific total mRNA expression from bulk data and shows its association with clinical outcomes across 15 cancer types.

Genomic and TCR Repertoire Intratumor Heterogeneity of Small-cell Lung Cancer and its Impact on Survival

This study examines genomic and TCR repertoire heterogeneity in SCLC, finding that lower TCR heterogeneity and mutational burden correlate with better survival.

Insights into the molecular basis of wooden breast based on comparative analysis of fast- and slow-growth broilers

This study identifies a polygenic, heritable basis for wooden breast in broilers through transcriptomic analysis and pathway enrichment, revealing complex molecular mechanisms beyond myopathy.