Karen L. Svenson

This study identifies six longevity-associated loci in Diversity Outbred mice through a genetic meta-analysis of lifespan data from three studies, explaining over half of the heritable variation in lifespan.

This study identifies and validates 22 genes that drive drug intake and related behavioral traits in mice through knockout screening and behavioral assays.

This study evaluates genomic prediction models incorporating gene transcripts and finds that transcript-based models improve accuracy when phenotypes are measured close to transcript sampling, but combining transcript and SNP data does not consistently outperform single-omics models.

This study compares linear models and gradient boosting machine for predicting complex traits in outbred mice, finding linear models generally outperform GBM, except for traits with epistatic effects.

The paper describes a process for cleaning SNP genotype data from Diversity Outbred mice, focusing on identifying and handling low-quality samples and markers.

This study identifies insertion sites in 40 transgenic mouse lines, revealing frequent disruptions of endogenous genes and structural variations.

The paper identifies 122 novel sleep-related genes from a large-scale knockout mouse study using non-invasive sleep monitoring.

The paper models epistatic networks in Diversity Outbred mice linking genetic variation, gene expression, and phenotypes related to metabolic disease and diet.

This study examines how sex and diet influence physiology and liver gene expression in Diversity Outbred mice, identifying genetic and sex-by-diet interactions affecting metabolic traits.