Author

Lionel Rougé

Denali Therapeutics (United States)ORCID 0000-0002-7953-5803Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A FortoniD· 1 shared Adedeji Daniel OgunyemiiD· 1 shared Ahana Dutta· 1 shared Ahlam N. QerqeziD· 1 shared Alexis L. RohouiD· 1 shared Anastasia G. HenryiD· 1 shared Andreas F. R. HühmeriD· 1 shared Ann Hong NguyeniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

A FortonORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Large-scale single-molecule analysis of tau proteoforms

James H. Joly, Vivekananda Budamagunta, Zhengjian Zhang, Brittany Nortman, Maryam Jouzi, Rajat Bhatnagar, Jarrett D. Egertson, Michael E. Flaster, Rob Grothe, Sanjib K Guha, Kota Kaneshige, Kevin McVey, Nicholas Nelson, Rukshan T. Perera, Steven J. Tan, , Cara Li

This paper introduces IMaP, a method to analyze tau proteoforms at the single-molecule level, revealing ordered phosphorylation patterns and disease-specific modifications.

Nature Methods · Sep 1, 2026Peer-reviewedBiochemistry

A Common PD-Risk GBA1 Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction

Oliver B. Davis, Jennifer E. Kung, Sonnet S. Davis, Rajarshi Ghosh, Shan V. Andrews, Neal S. Gould, Jillian H. Kluss, Elliot R. Thomsen, Maayan R. Agam, John P. Coan, Michael T. Maloney, Ann Hong Nguyen, Hoang Ngan Nguyen, Nicholas E. Propson, Edwin I. Lozano, , Anastasia G. Henry

This study shows the PD-risk GBA1 variant E326K reduces lysosomal GCase activity by disrupting LIMP2 interaction and causes lysosomal and mitochondrial dysfunction.

bioRxiv · Aug 28, 2025 · PreprintCell Biology