Prathapan Thiru

This study shows that targeting CD73 in quasi-mesenchymal breast tumors enhances their response to anti-CTLA4 therapy through CD4+ T-cell dependence.

This study shows that ether lipids in cancer cells regulate membrane properties to influence iron uptake, ferroptosis, and metastasis, offering a therapeutic target.

The paper shows that co-transcriptional splicing is essential for the transcription of gigantic genes in Drosophila, preventing transcript entanglement and ensuring proper gene expression.

This study identifies thyroid hormone receptor THRB as a key regulator of hepatocyte maturation from human PSCs, showing that T3 treatment enhances gene expression and epigenetic features of mature hepatocytes.

The paper quantifies Hsf1 binding and transcription in yeast under basal and heat shock conditions, revealing a continuum of Hsf1 occupancy and activity across the genome.

The paper develops a quantitative model to predict microRNA targeting efficacy in Drosophila, outperforming existing models and updating TargetScanFly.