Author

Giancarlo Pruneri

University of MilanORCID 0000-0002-7963-7172Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Claudio TripodoiD· 2 shared Valeria CancilaiD· 2 shared Adrian AndronacheiD· 1 shared Alessandra TucciiD· 1 shared Andrés J.M. FerreriiD· 1 shared Anojan SivacegaramiD· 1 shared Antonello Domenico CabrasiD· 1 shared Antonino BelfioreiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

Claudio TripodoORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ENPP3 expressed by HER2-positive breast cancer cells is associated with good prognosis by restraining epithelial-to-mesenchymal phenotype

Roberta Bongiorno, Maria Teresa Majorini, Valeria Figa', Davide Pernici, Matteo Dugo, Antonino Belfiore, Paolo Baili, Valeria Cancila, Elena Jachetti, Giancarlo Pruneri, Serenella Maria Pupa, Loris De Cecco, Tiziana Triulzi, Claudio Tripodo, Mario P. Colombo, , Daniele Lecis

This study shows that ENPP3 expression in HER2-positive breast cancer cells is linked to better prognosis by inhibiting epithelial-to-mesenchymal transition.

bioRxiv · Sep 1, 2026 · PreprintCancer Biology

B cell receptor silencing reveals the origin of high-grade B cell lymphomas with MYC and BCL2 rearrangements

Gabriele Varano, Silvia Lonardi, Paola Sindaco, Ilaria Pietrini, Gaia Morello, Piera Balzarini, Filippo Vit, Hadas Neuman, Giorgio Bertolazzi, Silvia Brambillasca, Nicara C. Parr, Marco Chiarini, Silvia Bellesi, Elena Maiolo, Sabrina Giampaolo, , Stefano S Casola

This paper shows that high-grade B cell lymphomas with MYC and BCL2 rearrangements originate from BCR-silenced follicular lymphoma cells that acquire IGL::MYC translocations, leading to resistance to CD79B-targeting therapy.

Blood Cancer Discovery · May 22, 2025Peer-reviewedCancer Biology

Loss of the tumor suppressor NUMB drives aggressive bladder cancer through hyperactivation of a RhoA/ROCK/YAP signaling circuitry

Francesco Antonio Tucci, Rosa Pennisi, Damiano Cosimo Rigiracciolo, Maria Grazia Filippone, R. Bonfanti, F. Romeo, Stefano Freddi, Elisa Guerrera, Chiara Soriani, Simona Rodighiero, Rosalind Helen Gunby, Giovanna Jodice, Francesca Sanguedolce, Giuseppe Renne, Nicola Fusco, , Salvatore Pece

This study identifies Numb loss as a driver of aggressive bladder cancer through hyperactivation of the RhoA/ROCK/YAP signaling pathway, proposing a 27-gene signature for clinical stratification.

Nature Communications · Dec 3, 2024Peer-reviewedCancer Biology