Author

Paul A. Dutchak

Université LavalORCID 0000-0002-7965-8870Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Chantelle F. SephtoniD· 2 shared Andrew D. NguyeniD· 1 shared Antoine DesmeulesiD· 1 shared Blair R. LeavittiD· 1 shared Denise M. SmithiD· 1 shared Frank RigoiD· 1 shared Geetika AggarwaliD· 1 shared Ian Mitchelle S. de VeraiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Chantelle F. SephtonORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

RAPTOR-targeted Antisense Oligonucleotides Restrict Pathological mTORC1 Activity in GATOR1-dependent Disease

Imane Hadj-Aissa, Maéline Muller, Antoine Desmeules, Laetitia Marcadet, Tristan Lachance-Brulotte, Nadine Morin, Marc‐Étienne Huot, Jorge Soliz, Chantelle F. Sephton, Paul A. Dutchak

This study develops RAPTOR-targeted ASOs to treat GATOR1-deficient diseases by reducing mTORC1 activity, improving neuronal function, and extending lifespan in models.

bioRxiv · Oct 8, 2026 · PreprintNeuroscience

Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation

Geetika Aggarwal, Subhashis Banerjee, Spencer A. Jones, Yousri Benchaar, Jasmine Bélanger, Myriam Sévigny, Denise M. Smith, Michael L. Niehoff, Monica Pavlack, Ian Mitchelle S. de Vera, Terri L. Petkau, Blair R. Leavitt, Karen Ling, Paymaan Jafar‐Nejad, Frank Rigo, , Andrew D. Nguyen

This study shows that antisense oligonucleotides can increase progranulin protein levels by blocking miR-29b binding in GRN mRNA, offering a potential therapy for FTD.

Journal of Biological Chemistry · Nov 17, 2023Peer-reviewedNeuroscience