Genevieve C. Sparagna

This study identifies a distinct mitochondrial metabolic phenotype in sedentary individuals using non-invasive CPET and finds reduced mitochondrial function and bioenergetics compared to active individuals.

This study compares mitochondrial and cardiolipin changes in pediatric and adult failing hearts before and after VAD support, finding age-related differences in cardiolipin remodeling and mitochondrial function.

This study investigates how serum factors and PDE5 inhibitor therapy affect cardiomyocyte metabolism in single ventricle heart disease, finding that PDE5 inhibitors improve mitochondrial function and metabolic intermediates.