Schwann Cell-Specific TDP-43 Rescue Improves Peripheral Nerve Myelin Pathology Without Altering Motor Behaviour in a Mouse Model of ALS
Katherine N. Lewis, Aaron Andres, Georgina Craig, Andrew Paul Tosolini, Robin Michael McAllen, Shyuan Thieu Ngo, David G. Gonsalvez, Bradley J. Turner, Samantha K. Barton
This study shows that rescuing Schwann cells in an ALS mouse model improves myelin structure but not motor function, highlighting the complex role of Schwann cells in disease progression.
bioRxiv · Jul 23, 2026 · PreprintNeuroscience