Author

Nathalie Danièle

Genethon (France)ORCID 0000-0002-7985-2788Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Abbass JaberiD· 1 shared Adeline Miranda· 1 shared Ai Vu HongiD· 1 shared Alexia Castiglione· 1 shared Antonia RattiiD· 1 shared Daniel StockholmiD· 1 shared David IsraeliiD· 1 shared Delphine BohliD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPhysiology

Abbass JaberORCID

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Author profile →

2 papers

Recent·Most cited

Pre-clinical evaluation of a gene therapy candidate for SOD1-ALS shows improved survival and signs of inflammation in the CNS of treated mice.

Sonia Pezet, Jennifer Hua, Thibaut Marais, Marine Delamare, Sahar Elouej, Julia P. Lemos, Alexia Castiglione, Stéphanie Astord, Mathilde Cohen-Tannoudji, Georges Arielle Pêche, Mara Rigamonti, Nathalie Danièle, Genries-Ferrand Sandrine, Laurine Buscara, Antonia Ratti, , Maria Grazia Biferi

This study evaluates a gene therapy for SOD1-ALS, showing improved survival and CNS inflammation in treated mice with dose-dependent hSOD1 reduction.

bioRxiv · Oct 16, 2025 · PreprintPharmacology & Toxicology

Targeting lysosomal damage is a new therapeutic perspective for Duchenne Muscular Dystrophy

Abbass Jaber, Laura Palmieri, Rania Bakour, Elise Lachiver, Ai Vu Hong, Nathalie Bourg, Jérôme Poupiot, Sonia Albini, Daniel Stockholm, Laetitia van Wittenberghe, Adeline Miranda, Nathalie Danièle, Inès Barthélémy, Stéphane Blot, Mai Thao Bui, , David Israeli

This study identifies lysosomal damage as a novel mechanism in Duchenne Muscular Dystrophy and shows that combining trehalose with gene therapy improves outcomes.

bioRxiv · Feb 11, 2025 · PreprintPhysiology