Author

Alexia Castiglione

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Alexandre GallerandiD· 3 shared Stoyan IvanoviD· 3 shared Zakariya Caillot· 3 shared Adeline BertolaiD· 2 shared Bastien DolfiiD· 2 shared David DombrowicziD· 2 shared Eloïse Goës· 2 shared Evy Boré· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Alexandre GallerandORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CSF1R regulates monocyte subset differentiation and intracellular metabolism.

Alexandre Gallerand, Johanna Merlin, Zakariya Caillot, Chloe Delaby, Elisa Bord, Jichang Han, Bastien Dolfi, Michael D. Chang, Guilhem R. Thierry, Alexia Castiglione, Sacha Grenet, Eloïse Goës, Maxime Franceschini, Gisèle Jarretou, Fairouz N. Zair, , Stoyan Ivanov

This study shows that CSF1R regulates monocyte differentiation and metabolism, with its blockade reducing Ly6Clow monocytes and affecting subset diversity through the hexosamine biosynthetic pathway.

Nature Communications · Jul 4, 2026Peer-reviewedImmunology

p16High immune cell - controlled disease tolerance as a broad defense and healthspan extending strategy

Francisco Triana-Martínez, Alessandra Pierantoni, Daisy Graça, Veronica Bergo, Alexander Emelyanov, Alexandre Gallerand, Laurent Grosse, Bogdan B. Grigorash, Aikaterini Polyzou, Alexia Castiglione, Shunya Tsuji, Sosuke Nakano, Vesna Brglez, Zakariya Caillot, Pierre Marty, , Dmitry V. Bulavin

This study identifies p16High immune cells as critical for disease tolerance, showing they enhance survival in various conditions and extend healthspan by maintaining low adenosine levels.

Immunity · Mar 26, 2026Peer-reviewedCell Biology

Pre-clinical evaluation of a gene therapy candidate for SOD1-ALS shows improved survival and signs of inflammation in the CNS of treated mice.

Sonia Pezet, Jennifer Hua, Thibaut Marais, Marine Delamare, Sahar Elouej, Julia P. Lemos, Alexia Castiglione, Stéphanie Astord, Mathilde Cohen-Tannoudji, Georges Arielle Pêche, Mara Rigamonti, Nathalie Danièle, Genries-Ferrand Sandrine, Laurine Buscara, Antonia Ratti, , Maria Grazia Biferi

This study evaluates a gene therapy for SOD1-ALS, showing improved survival and CNS inflammation in treated mice with dose-dependent hSOD1 reduction.

bioRxiv · Oct 16, 2025 · PreprintPharmacology & Toxicology

CD226+ macrophages arise from MDP-derived monocytes and regulate lipid metabolism.

Alexandre Gallerand, Zakariya Caillot, Frederike Westermann, Selma Tuzlak, Sacha Grenet, Marina Terekhova, Alexia Castiglione, Thomas Pilot, Laurent L’homme, Kerim Acil, Lorlana Leporati, Margaux Giacchero, Eloïse Goës, Maxime Franceschini, Sebastien Fleury, , Stoyan Ivanov

The paper identifies CD226high macrophages derived from MDP monocytes as a new myeloid cell type involved in lipid metabolism regulation across tissues.

bioRxiv · Dec 3, 2024 · PreprintImmunology