Author

Zoltán Orgován

HUN-REN Research Centre for Natural SciencesORCID 0000-0002-8002-3047Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

György Miklós KeserűiD· 2 shared Péter Ábrányi‐BaloghiD· 2 shared Christoph RademacheriD· 1 shared Dávid BajusziD· 1 shared Emma K. GrantiD· 1 shared Gitta SchlosseriD· 1 shared Iris A. BermejoiD· 1 shared István KolossváryiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiophysics

György Miklós KeserűORCID

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2 papers

Recent·Most cited

Efficient detection of cryptic pockets on challenging drug targets using MD-free co-vibrational modes

Tibor Viktor Szalai, Dávid Bajusz, Zoltán Orgován, Péter Ábrányi‐Balogh, Márton Gadanecz, Tı́mea Imre, Emma K. Grant, Jacob T. Bush, István Kolossváry, György Miklós Keserű

The paper identifies cryptic pockets on challenging drug targets using a fast MD-free method and validates them experimentally.

bioRxiv · Oct 8, 2026 · PreprintBiophysics

Covalent activation of the C-type lectin DC-SIGN

Jonathan Lefèbre, Maurice Besch, Noémi Csorba, Kristóf Noel Garami, Zoltán Orgován, Gitta Schlosser, Iris A. Bermejo, Péter Ábrányi‐Balogh, György Miklós Keserű, Christoph Rademacher

This paper identifies two covalent activators of DC-SIGN by screening a lysine-targeted electrophilic fragment library, revealing distinct mechanisms of activation through structural and functional analyses.

Angewandte Chemie International Edition · Nov 24, 2025Peer-reviewedPharmacology & Toxicology