Author

Ian Hector Frazer

The University of QueenslandORCID 0000-0002-8002-4680Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Approach:deep learning· 2 Assay:metagenomics· 2 Research Focus:spatial domain detection· 2 Assay:spatial transcriptomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Andrew CauseriD· 2 shared Blake O’BrieniD· 2 shared Hani VuiD· 2 shared Janin ChandraiD· 2 shared Quan Hoang NguyeniD· 2 shared Zherui XiongiD· 2 shared Ahmed Murtaza MehdiiD· 1 shared Alena L. PribyliD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersGenomics

Andrew CauserORCID

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Author profile →

4 papers

Recent·Most cited

Spatial analysis of HPV associated cervical intraepithelial neoplastic tissues demonstrate distinct immune signatures associated with cervical cancer progression

Gianna Louise Pavilion, Hani Vu, Zherui Xiong, Thi Viet Trinh Dang, Blake O’Brien, Michael D. Walsh, Andrew Causer, Janin Chandra, Quan Hoang Nguyen, Ian Hector Frazer

The paper analyzes spatial immune signatures in HPV-associated cervical tissues to identify immune modulation patterns linked to cancer progression.

The Journal of Pathology · Dec 9, 2025Peer-reviewedGenomics

Integrating 12 Spatial and Single Cell Technologies to Characterise Tumour Neighbourhoods and Cellular Interactions in three Skin Cancer Types

P. Prakrithi, Laura F. Grice, Feng Zhang, Levi Hockey, Samuel X. Tan, Xiao Tan, Zherui Xiong, Onkar Mulay, Andrew Causer, Andrew Newman, Duy Pham, Guiyan Ni, Zewen Kelvin Tuong, Xinnan Jin, Eun Ju Kim, , Quan Hoang Nguyen

The paper integrates 12 spatial and single-cell technologies to analyze cellular interactions and signatures in three skin cancers, identifying key therapeutic targets and genetic associations.

bioRxiv · Jul 25, 2025 · PreprintCancer Biology

A rational approach for the targeted discovery and characterisation of microbiome-derived therapeutics

Lutz Krause, Joel A. Boyd, Charlotte Vivian, Annika Krueger, Jeimy Johana Jimenez Loayza, Johanna K. Ljungberg, Joyce Zhou, Andrea Rabellino, Bozica Nyeverecz, Michael D. Nissen, Kaylyn D. Tousignant, Mareike Bongers, Martha M. Cooper, Donovan H. Parks, Areej S. Alsheikh-Hussain, , Páraic Ó Cuív

This paper identifies microbiome-derived therapeutics for IBD using a metagenome-guided approach, showing improved disease markers and safety in preclinical models.

bioRxiv · Oct 22, 2024 · PreprintMicrobiology

E.PAGE: A curated database and enrichment tool to predict modules associated with gene-environment interactions

Sachin Muralidharan, Sarah Ali, Lilin Yang, Joshua Sam Badshah, Syeda Farah Zahir, Rubbiya A. Ali, Janin Chandra, Ian Hector Frazer, Ranjeny Thomas, Ahmed Murtaza Mehdi

The paper curates a database and develops an R package to identify gene-environment interactions by analyzing gene modules associated with environmental factors in disease.

bioRxiv · Jan 3, 2022 · PreprintGenomics