Author

Iris Dotan

Tel Aviv UniversityORCID 0000-0002-8005-7706Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alison D. AxtmaniD· 1 shared Ani MichaudiD· 1 shared Dror S. ShouvaliD· 1 shared Efrat Shaham Barda· 1 shared Frances M. BashoreiD· 1 shared Hadas Keren‐ShauliD· 1 shared Hagar Banai Eran· 1 shared Henit YanaiiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

Alison D. AxtmanORCID

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3 papers

Recent·Most cited

Persistent stromal reprogramming defines incomplete mucosal healing and predicts therapeutic response in ulcerative colitis

Mor Hindi Malowany, Yaniv Stein, Rachel Frieman-Sharabi, Oshrat Galibov-Levi, Neta Yanir, Merav Kedmi, Maor H. Pauker, Manar Matar, Yifat Snir, Noa Tal, Hagar Banai Eran, Yael Weintraub, Sara Morgenstern, Ofra Golani, Inna Goliand, , Ruth Scherz‐Shouval

The paper identifies persistent stromal reprogramming in mucosal healing of ulcerative colitis and links it to therapeutic response prediction.

bioRxiv · Jun 10, 2026 · PreprintImmunology

Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants

Jacob L. Capener, James D. Vasta, Vittorio L. Katis, Ani Michaud, Michael Beck, S. C. D. Daglish, Sarit Cohen‐Kedar, Efrat Shaham Barda, Stefanie Howell, Iris Dotan, Matthew B. Robers, Alison D. Axtman, Frances M. Bashore

The paper develops a NanoBRET assay to study SYK gain-of-function variants in live cells and demonstrates inhibitor efficacy against these variants.

Frontiers in Chemical Biology · Jul 29, 2024Peer-reviewedCell Biology

Escherichia coli strains from patients with inflammatory bowel diseases have disease-specific genomic adaptations

Vadim Dubinsky, Leah Reshef, Keren Masha Rabinowitz, Nir Wasserberg, Iris Dotan, Uri Gophna

The paper analyzes E. coli genomes from IBD patients to identify disease-specific genomic adaptations and their functional implications.

Journal of Crohn s and Colitis · May 13, 2022Peer-reviewedGenomics