'Target-and-release' nanoparticles for effective immunotherapy of metastatic ovarian cancer
Ivan Susin Pires, Gil Covarrubias, Victoria F. Gomerdinger, Coralie M. Backlund, Eduardo Nombera Bueno, Margaret M. Billingsley, Mae L. Pryor, Apoorv Shanker, Ezra Gordon, Shengwei Wu, Andrew J. Pickering, Mariane B. Melo, Heikyung Suh, Darrell J. Irvine, Paula Therese Hammond
This study develops IL-12-loaded nanoparticles that enhance immunotherapy for metastatic ovarian cancer by promoting T cell accumulation and sensitizing tumors to checkpoint inhibitors.
Nature Materials · Oct 31, 2025Peer-reviewedBioengineering