Margaret M. Billingsley

This study shows that the outer polyion layer of layer-by-layer nanoparticles affects protein corona formation, which influences their biodistribution and therapeutic efficacy.

This paper develops a multivalent peptide-polymer conjugate that mimics STING to activate innate immune signaling and shows tumor regression in ovarian cancer models.

The paper shows that anionic polypeptide coatings on nanoparticles bind to cancer-associated amino acid transporters, enabling targeted drug delivery through electrostatic interactions and transporter clustering.

This study develops IL-12-loaded nanoparticles that enhance immunotherapy for metastatic ovarian cancer by promoting T cell accumulation and sensitizing tumors to checkpoint inhibitors.