Carine Froment

The paper analyzes translatome and translation dynamics in RiboCancer cell lines to show that Rps15 mutations disrupt tRNA accommodation, affecting translation efficiency and transcriptional regulation in CLL.

The paper uses cryo-EM and simulations to reveal how LptM and LptY facilitate LPS transport by modulating LptD conformational dynamics in the translocon complex.

This study identifies ribosome biogenesis as a therapeutic vulnerability in TNBC, showing that inhibiting rRNA maturation via Fibrillarin or RNA Pol I reduces tumor growth without significant cell death.

The paper identifies SURF2 as a MDM2 antagonist that modulates nucleolar stress responses by buffering free-5S RNP particles, linking it to cancer resistance and patient survival.

The paper identifies Neat1 and paraspeckle components as translational regulators that facilitate IRES-dependent translation during hypoxia in mouse cardiomyocytes.

This study shows that attaching RNase E to the inner cytoplasmic membrane in E. coli prevents the degradation of rRNA intermediates during ribosome assembly, explaining the evolutionary conservation of this localization.

The paper shows RSK phosphorylates RIOK2, promoting pre-40S particle maturation and ribosome synthesis in human cells.

The paper identifies a dual key lock mechanism involving RIO1 and RPS26 that controls the final maturation step of 40S ribosomal subunits by displacing DIM2 and enabling NOB1-mediated cleavage of 18S rRNA.