Miles Sasha Dickinson

This study determines the cryo-EM structures of human ABCD3 in apo and substrate-bound states, revealing how substrate binding induces ATPase activity and provides structural insights into its transport mechanism.

This study identifies four antibody mechanisms that disrupt FimH-mediated bacterial adhesion by altering its conformation and glycan binding.

The paper isolates two human monoclonal antibodies that broadly neutralize PDCoV variants and identifies their mechanism of action.

The paper shows that missense mutations in kinetochore proteins reduce chromosome instability in histone-humanized yeast by weakening microtubule attachments, promoting euploidy.

The paper uses deep mutational scanning to explore how chemical perturbations affect ubiquitin's mutational tolerance, revealing sensitization of most positions except two.