Nitesh Khandelwal

Molecular mechanism of substrate transport by human peroxisomal ABCD3

This study determines the cryo-EM structures of human ABCD3 in apo and substrate-bound states, revealing how substrate binding induces ATPase activity and provides structural insights into its transport mechanism.

Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporterefflux protein A

This study identifies two inhibitors of the Mtb efflux pump EfpA, determines their binding mechanisms, and suggests their potential for combination anti-tuberculosis therapy.

Structural basis of autoantibody binding in Neuromyelitis Optica

This study determines the structural basis of autoantibody binding to aquaporin-4 in NMO, revealing epitope diversity on tetrameric and higher-order assemblies.