Max A. B. Haase

Ancient co-option of LTR retrotransposons as yeast centromeres

The paper identifies proto-point centromeres in Saccharomycodales yeast, showing they evolved from retrotransposon LTRs, supporting the hypothesis that point centromeres originated from ancestral retrotransposons.

Engineered transcription-associated Cas9 targeting in eukaryotic cells

This paper introduces a method to temporally control Cas9 DNA targeting by coupling it with transcription through engineered RNA binding, enabling selective gene editing in yeast and human cells.

Human macroH2A1 drives nucleosome dephasing and genome instability in histone-humanized yeast

This study replaces human variant histones in yeast, showing macroH2A1 disrupts chromatin organization and causes genome instability.

Manipulating the 3D organization of the largest synthetic yeast chromosome

This paper synthesizes the largest eukaryotic yeast chromosome, synIV, and investigates how its 3D structure affects gene regulation and transcription.

Humanized nucleosomes reshape replication initiation and rDNA/nucleolar integrity in yeast

This study examines how humanized nucleosomes in yeast affect chromatin structure, replication, and rDNA stability, revealing species-specific impacts on nuclear organization and function.

DASH/Dam1 complex mutants stabilize ploidy by weakening kinetochore-microtubule attachments

The paper shows that missense mutations in kinetochore proteins reduce chromosome instability in histone-humanized yeast by weakening microtubule attachments, promoting euploidy.

Stable twin rDNA loci form a single nucleolus in brewer's yeast

This study shows that twin rDNA loci in brewer's yeast form a single nucleolus and reveals position-dependent size changes in rDNA loci.

Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples.

This study uses whole genome sequencing and phenotyping to analyze 77 C. tropicalis isolates, identifying hybrid lineages and a genomic variant affecting nitrogen utilization.

Repeated horizontal gene transfer of GALactose metabolism genes violates Dollo's law of irreversible loss

The paper shows that galactose metabolism genes can be horizontally transferred between yeast species, allowing for the reacquisition of a lost trait after millions of years.

Superloser: a plasmid shuffling vector for Saccharomyces cerevisiae with exceedingly low background

The paper introduces Superloser, a plasmid shuffling vector for yeast that enables efficient gene pathway replacement with low background.