Author

Kelli L. Hvorecny

University of WashingtonORCID 0000-0002-4609-6170Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Anna A. ManchenkoiD· 2 shared Evgeni V. SokurenkoiD· 2 shared Gianluca InterlandiiD· 2 shared Pavel AprikianiD· 2 shared Pearl MagalaiD· 2 shared Rachel E. KlevitiD· 2 shared Veronika L TchesnokovaiD· 2 shared Aaron J. SchmitziD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

Anna A. ManchenkoORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

De Novo Design of Miniprotein Inhibitors of Bacterial Adhesins

Adam M. Chazin-Gray, Tuscan Rock Thompson, Edward D. B. Lopatto, Pearl Magala, Patrick W. Erickson, Andrew C. Hunt, Anna A. Manchenko, Pavel Aprikian, Veronika L Tchesnokova, Irina Basova, Denise A. Sanick, Kevin O. Tamadonfar, Morgan R. Timm, Jerome S. Pinkner, Karen Dodson, , David A. Baker

This study designs miniprotein inhibitors targeting bacterial adhesins to prevent and treat urinary tract infections.

Nature Communications · Oct 9, 2026Peer-reviewedMicrobiology

Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference

Kelli L. Hvorecny, Gianluca Interlandi, Tim S. Veth, Pavel Aprikian, Anna Manchenko, Veronika L Tchesnokova, Miles Sasha Dickinson, Joel D. Quispe, Nicholas McIlvain Riley, Rachel E. Klevit, Pearl Magala, Evgeni V. Sokurenko, Justin M. Kollman

This study identifies four antibody mechanisms that disrupt FimH-mediated bacterial adhesion by altering its conformation and glycan binding.

Nature Communications · Nov 26, 2025Peer-reviewedImmunology