Author

Joel D. Quispe

University of WashingtonORCID 0000-0002-3693-4935Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Immunology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Assay:structural biology· 2 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1

Frequent Co-Authors

David VeesleriD· 3 shared Young‐Jun ParkiD· 3 shared Daniel E. AsarnowiD· 2 shared Jack T BrowniD· 2 shared Justin M. KollmaniD· 2 shared Miles Sasha DickinsoniD· 2 shared Adam P. MoyeriD· 1 shared Alessio Balmelli· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiochemistry

David VeeslerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference

Kelli L. Hvorecny, Gianluca Interlandi, Tim S. Veth, Pavel Aprikian, Anna Manchenko, Veronika L Tchesnokova, Miles Sasha Dickinson, Joel D. Quispe, Nicholas McIlvain Riley, Rachel E. Klevit, Pearl Magala, Evgeni V. Sokurenko, Justin M. Kollman

This study identifies four antibody mechanisms that disrupt FimH-mediated bacterial adhesion by altering its conformation and glycan binding.

Nature Communications · Nov 26, 2025Peer-reviewedImmunology

SARS-CoV-2 nsp1 mediates broad inhibition of translation in mammals

Risako Gen, Amin Addetia, Daniel E. Asarnow, Young‐Jun Park, Joel D. Quispe, Matthew C. Chan, Jack T Brown, Jimin Lee, Melody G. Campbell, Christopher P. Lapointe, David Veesler

This study shows SARS-CoV-2 nsp1 inhibits translation in bat cells and human cells, revealing its broad activity across mammals.

Cell Reports · May 1, 2025Peer-reviewedBiochemistry

Broadly neutralizing antibodies against emerging delta-coronaviruses

Megi Rexhepaj, Daniel E. Asarnow, Lisa Perruzza, Young‐Jun Park, Barbara Guarino, Mathew Mccallum, Katja Culap, Christian Saliba, Giada Leoni, Alessio Balmelli, Courtney N. Yoshiyama, Miles Sasha Dickinson, Joel D. Quispe, Jack T Brown, M. Alejandra Tortorici, , David Veesler

The paper isolates two human monoclonal antibodies that broadly neutralize PDCoV variants and identifies their mechanism of action.

Immunity · Nov 1, 2024Peer-reviewedBiochemistry

Computational design of nanoscale rotational mechanics in de novo protein assemblies

Alexis Courbet, Jesse M. Hansen, Yang Hsia, Neville P. Bethel, Young‐Jun Park, Chunfu Xu, Adam P. Moyer, Scott E. Boyken, George Ueda, Una Nattermann, Deepesh Nagarajan, Daniel‐Adriano Silva, William Sheffler, Joel D. Quispe, Ashley L. Nord, , David A. Baker

This paper computationally designs self-assembling protein rotary machines that sample internal rotational degrees of freedom based on energy landscapes.

Science · Apr 21, 2022Peer-reviewedSynthetic Biology