Stephanie Halene

This study identifies MGMT silencing as a therapeutic target in AML and shows that combining O6-fluoroethylating agents with ATR inhibitors improves treatment outcomes.

This study maps age-related cellular senescence in human lymph nodes, identifying senescence markers and spatial shifts in germinal center B cells.

The paper introduces Cell Marker Accordion, a tool for accurate and interpretable single-cell and spatial omics annotation across health and disease contexts.

This study shows that the RBM15-MKL1 fusion protein drives leukemia through m6A methylation and WNT pathway activation, with METTL3 inhibition reducing tumor growth.

This study identifies epigenetic subtypes of MDS using DNA methylation patterns and develops a predictive signature for azacitidine response.

This study identifies NAT10 as a master regulator of brain metastasis through an in vivo shRNA screen and shows its role in promoting tumor growth and metastasis via downstream effectors.

This study identifies a nuclear role for AGO2 in spermatogenesis, showing it enhances protein expression by interacting with splicing and chromatin factors.

This paper introduces spatial-ATAC-seq, a method for spatially resolved chromatin accessibility profiling at the cellular level, and demonstrates its application in mouse embryos and human tonsil tissue.

Spatial-CITE-seq profiles proteins and transcriptomes in tissues, revealing spatially distinct immune responses in mouse and human tissues.

DBiT-seq enables high-spatial-resolution multi-omics mapping of mouse embryos by deterministic barcoding, revealing tissue types and fine features like retinal pigmented epithelium and microvasculature.

The paper was withdrawn due to a duplicate posting and directs readers to the current version on bioRxiv.