Paula Murphy

Biological Signaling Pathways Associated with Late Tendon Development in Chicken Embryos and Their Dependence on Mechanical Stimulation

This study identifies mechanotransduction pathways involved in chicken tendon development and shows how paralysis disrupts these processes.

Embryo movement is required for limb tendon maturation

The paper shows that embryo movement is essential for tendon maturation in chick embryos, with YAP signaling and collagen alignment responding to mechanical cues.

Integrated analysis of Wnt signalling system component gene expression

The paper maps Wnt and Fzd gene expression across mouse embryos in 3D space to identify novel co-expression territories and regions with unique or no expression.

WlzWarp: An Open-Source Tool for Complex Alignment of Spatial Data

WlzWarp is an open-source tool for aligning complex spatial data, tested on mouse embryo gene-expression patterns.

Mechanical Stimulation via Muscle Activity is Necessary for the Maturation of Tendon Multiscale Mechanics during Embryonic Development

This study shows that mechanical stimulation via muscle activity is necessary for tendon maturation during embryonic development, as it affects both macroscale mechanics and microscale collagen structure.

Joint development recovery on resumption of embryonic movement following paralysis

The study shows that movement after embryonic paralysis can partially recover joint development in chick embryos, with varying effectiveness across limb joints.

Effects of abnormal muscle forces on prenatal joint morphogenesis in mice

This study quantifies how reduced or absent muscle affects joint shape in mouse embryos, finding that reduced muscle has more pronounced effects than absent muscle, particularly on the elbow joint.