The SUMOylation inhibitor TAK-981 (Subasumstat) triggers IFN-I-dependent activation of Natural Killer cells against Acute Myeloid Leukemias.
Rawan Hallal, Marion de Toledo, Denis Tempé, Rayane Berrahouane, Sara Zemiti, Loïs Coënon, Delphine Gitenay, Simon George, Moritz Schüssler, Nadine Laguette, Sarah Bonnet, Ludovic Gabellier, Guillaume Cartron, Mireia Pelegrín, Martín Villalba, Guillaume Bossis
This paper shows that TAK-981 activates NK cells against AML by inducing IFN-I secretion, enhancing their cytotoxicity and cytokine production.
Molecular Cancer Therapeutics · Jul 15, 2025Peer-reviewedCancer Biology