Moritz Schüssler

The RLR-MAVS-IRF3 axis activates the IFN pathway to restrict Tonate virus (TONV) infection

This study identifies the RIG-I/MDA5-MAVS-IRF3 axis as the pathway sensing TONV infection and activating the IFN-I response to restrict viral replication.

DNA-PK interacts with cyclic dinucleotides and inhibits type I Interferon responses

The paper identifies DNA-PKcs as a regulator of cyclic dinucleotide signaling, showing it interacts with CDN and modulates STING activation and antiviral responses.

The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling

This study shows that MECP2 inhibits cGAS signaling by exporting to the cytosol upon dsDNA detection, dampening inflammation and antiviral responses.