Chi Gidley Weindel

Mitochondrial STAT3-mediated suppression of apoptosis constrains antimycobacterial immunity

This study identifies Trim14's role in suppressing apoptosis via mitochondrial Stat3 during Mtb infection, enhancing antimycobacterial immunity.

Fragile X messenger ribonucleoprotein modulates IL-6 induction and inflammatory cell death in macrophages

This study shows that FMRP modulates IL-6 induction and inflammatory cell death in macrophages during Listeria monocytogenes infection.

LRRK2 kinase activity restricts NRF2-dependent mitochondrial protection in microglia

This study shows that LRRK2 kinase activity in microglia restricts NRF2-dependent mitochondrial protection, contrasting with its role in peripheral macrophages.

Necrosis drives susceptibility to Mycobacterium tuberculosis in PolgD257A mutator mice

This study shows that mtDNA mutations in PolgD257A mice increase susceptibility to Mtb by impairing innate immunity and promoting necrosis.

SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX

This study identifies SRSF6 as a regulator of mitochondrial homeostasis in macrophages through alternative splicing of BAX, influencing immune responses and inflammation.