Thomas A. Bowden

This study isolates and characterizes monoclonal antibodies against Nipah virus from an mRNA-immunized pig, showing their neutralizing activity and potential for therapeutic use.

The paper designs and experimentally validates mini-protein binders targeting receptor-binding domains of Nipah, Langya, and Measles viruses using computational tools and limited screening.

This paper improves the expression and stability of influenza neuraminidase by grafting antigenic loops from low-expressing variants onto high-expressing scaffolds, resulting in vaccine-effective hybrid proteins.

The paper determines the crystal structures of New World arenavirus GP1-GP2 complexes, revealing structural differences from Old World counterparts and demonstrating their antigenic relevance for vaccine development.

The paper identifies a deletion mutation in the spike protein of SARS-CoV-2 and examines its presence in clinical and in vitro samples, suggesting potential implications for viral replication and vaccine development.

This paper identifies nine T cell epitopes in the Ebolavirus glycoprotein and shows they are presented by multiple HLA alleles, suggesting broad immune recognition.