Guido C. Paesen

The paper determines the structure of C-type lectins in Aedes aegypti, revealing a conserved dimeric arrangement that facilitates carbohydrate recognition in vector-pathogen interactions.

This paper improves the expression and stability of influenza neuraminidase by grafting antigenic loops from low-expressing variants onto high-expressing scaffolds, resulting in vaccine-effective hybrid proteins.

The paper determines the crystal structures of New World arenavirus GP1-GP2 complexes, revealing structural differences from Old World counterparts and demonstrating their antigenic relevance for vaccine development.