Author

Alain Townsend

John Radcliffe HospitalORCID 0000-0002-3702-0107Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Alexander A. CoheniD· 1 shared David Ian StuartiD· 1 shared Diana MelnykiD· 1 shared Guido C. PaeseniD· 1 shared Jennifer R. KeeffeiD· 1 shared Jonathan MunroiD· 1 shared Kuan-Ying Arthur HuangiD· 1 shared Leiyan Wei· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Alexander A. CohenORCID

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2 papers

Recent·Most cited

Development of a Recombinant Single-Cycle Influenza Viral Vector as an Intranasal Vaccine against SARS-CoV-2 and SARS-like Betacoronaviruses

Jonathan Munro, Diana Melnyk, Madeeha Afzal, Lisa Schimanski, Alexander A. Cohen, Jennifer R. Keeffe, Pamela J. Björkman, William James, Alain Townsend, Tiong Kit Tan

This paper develops a recombinant single-cycle influenza viral vector vaccine against SARS-CoV-2 and SARS-like betacoronaviruses, showing robust immune responses in mice.

bioRxiv · Nov 28, 2025 · PreprintImmunology

Structure-Guided Loop Grafting Improves Expression and Stability of Influenza Neuraminidase for Vaccine Development

Pramila Rijal, Leiyan Wei, Guido C. Paesen, David Ian Stuart, Mark R. Howarth, Kuan-Ying Arthur Huang, Thomas A. Bowden, Alain Townsend

This paper improves the expression and stability of influenza neuraminidase by grafting antigenic loops from low-expressing variants onto high-expressing scaffolds, resulting in vaccine-effective hybrid proteins.

bioRxiv · Oct 11, 2024Immunology