Wei Chen

Gene Expression Reactomes Across Species Do Not Correlate with Gene Structural Similarity

The paper measures gene expression responses to drugs in mouse and rat genomes across organs and finds that reactomes do not correlate with structural similarity, proposing a new cross-species mapping approach based on expression patterns.

Common postzygotic mutational signature in multiple healthy adult tissues related to embryonic hypoxia

The paper identifies a common postzygotic mutational signature across healthy tissues linked to embryonic hypoxia, observed in both normal and some tumor samples.

Epigenetic Effects of Assisted Reproductive Technology in Human Offspring

This study examines the epigenetic effects of assisted reproductive technologies on human offspring, finding that certain procedures introduce DNA methylation changes linked to long-term health risks.

An evidence-based approach to globally assess the covariate-dependent effect of MTHFR SNP rs1801133 on plasma homocysteine: a systematic review and meta-analysis

This paper assesses how the MTHFR SNP rs1801133 affects plasma homocysteine levels, considering covariates like folic acid intake, and finds significant variability due to effect modification and confounding.