Liying Yan

The paper uses single oocyte full-length isoform sequencing to identify novel transcripts and show that transposable elements contribute to RNA isoform diversity and stability during oocyte maturation.

The paper identifies a mutation in PIEZO1 that abolishes mechanical activation but not chemical activation, showing a direct link between mechanosensitivity and fetal hydrops.

GametesOmics integrates multi-omics data from human and mouse gametogenesis to provide tools for analyzing gene expression, DNA methylation, and chromatin accessibility.

This study develops a single-cell multiomics sequencing method to analyze epigenetic and transcriptional dynamics in mouse preimplantation embryos, revealing regulatory networks and lineage specification mechanisms.

This study uses single-cell RNA-seq to evaluate ACE2 expression in ovarian tissues across developmental stages, identifying high ACE2 expression in PGCs and COC and its potential role in SARS-CoV-2 infection risk.

This study investigates the epigenetic effects of prenatal testosterone transfer between opposite-sex twins using DNA methylation and histone modification data, finding distinct epigenetic signatures linked to cognition, nervous system, and immune responses.

The paper introduces GeACT, a genomic database for human mid-gestation fetus cells, linking gene expression to chromatin states and identifying key transcription factors.

This study examines the epigenetic effects of assisted reproductive technologies on human offspring, finding that certain procedures introduce DNA methylation changes linked to long-term health risks.

This study profiles the transcriptomes of human oocytes and granulosa cells across folliculogenesis stages, identifying stage-specific genes, cell interactions, and differences from mouse oocytes.