Bart Spee

This study develops bioengineered liver tissues using multiple cell types and synthetic hydrogels, showing improved structure, function, and maturation.

This study optimizes the isolation, expansion, and differentiation of canine intestinal organoids, showing improved stem cell proliferation and functional marker expression.

This paper develops a liver organoid-on-a-chip model using hollow fiber membranes to study drug metabolism and transport, showing improved hepatocyte-like maturation and functional drug processing.

This study develops hepatocyte-like liver organoids (HeLLOs) that closely mimic mature hepatocyte functions and outperform existing models in drug toxicity testing and disease modeling.

This study develops a method to generate and expand hepatobiliary organoids from adult human hepatocytes, which retain liver function and can model liver diseases.