Author

Indi P. Joore

University Medical Center Utrecht

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell-cell communication· 1 Assay:organoid / primary culture· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Sabine A. FuchsiD· 4 shared Edward E. S. NieuwenhuisiD· 3 shared Imre Firmin ScheneiD· 3 shared Adam MyszczyszyniD· 2 shared Arif Ibrahim ArdisasmitaiD· 2 shared Ary MarseeiD· 2 shared Bart SpeeiD· 2 shared Hubert P. J. van der DoefiD· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersCell Biology

Sabine A. FuchsORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Novel hepatocyte-like liver organoids recapitulate crucial mature hepatic functions

Arif Ibrahim Ardisasmita, Indi P. Joore, N. Levy, Adam Myszczyszyn, Ary Marsee, Theo L. Sinnige, Jos P.N. Ruiter, Sacha Ferdinandusse, Oksana Y. Dudaryeva, E. Gruber, V. Daive, Riccardo Levato, Bart Spee, Monique M. A. Verstegen, Luc J. W. van der Laan, , Sabine A. Fuchs

This study develops hepatocyte-like liver organoids (HeLLOs) that closely mimic mature hepatocyte functions and outperform existing models in drug toxicity testing and disease modeling.

bioRxiv · Oct 29, 2024 · PreprintCell Biology

Mass Generation and Long-term Expansion of Hepatobiliary Organoids from Adult Primary Human Hepatocytes

Ary Marsee, Arabela Ritchie, Adam Myszczyszyn, Shicheng Ye, Jung‐Chin Chang, Arif Ibrahim Ardisasmita, Indi P. Joore, Jose Castro-Alpízar, Sabine A. Fuchs, Kerstin Schneeberger, Bart Spee

This study develops a method to generate and expand hepatobiliary organoids from adult human hepatocytes, which retain liver function and can model liver diseases.

bioRxiv · Jun 10, 2024 · PreprintCell Biology

Mutation-specific reporter for the optimization and enrichment of prime editing

Imre Firmin Schene, Indi P. Joore, Jan H. L. Baijens, Remi Stevelink, Gautam Kok, Sawsan Shehata, Eveline F. Ilcken, E. C. M. Nieuwenhuis, Dian Bolhuis, R. C. M. van Rees, Sacha Spelier, Hubert P. J. van der Doef, Jeffrey Matthijn Beekman, Roderick H.J. Houwen, Edward E. S. Nieuwenhuis, Sabine A. Fuchs

This paper introduces a fluorescent reporter system for evaluating and enhancing prime editing efficiency in genomic targets.

Nature Communications · Mar 1, 2022Peer-reviewedMolecular Biology

Prime editing for functional repair in patient-derived disease models

Imre Firmin Schene, Indi P. Joore, Rurika Oka, Michal Mokrý, Anke H.M. van Vugt, Ruben van Boxtel, Hubert P. J. van der Doef, Luc J. W. van der Laan, Monique M. A. Verstegen, Peter M. van Hasselt, Edward E. S. Nieuwenhuis, Sabine A. Fuchs

This paper demonstrates the use of prime editing to correct genetic mutations in patient-derived organoids, showing high efficiency and precision with minimal off-target effects.

Nature Communications · Oct 23, 2020Peer-reviewedGenomics