Sabine A. Fuchs

Multiscale three-dimensional ultrastructural mapping of intestinal tissues and organoids

This study uses expansion microscopy to analyze three-dimensional ultrastructure of intestinal tissues and organoids, revealing disease-specific phenotypes in a microvillus inclusion disease model.

Novel hepatocyte-like liver organoids recapitulate crucial mature hepatic functions

This study develops hepatocyte-like liver organoids (HeLLOs) that closely mimic mature hepatocyte functions and outperform existing models in drug toxicity testing and disease modeling.

Mass Generation and Long-term Expansion of Hepatobiliary Organoids from Adult Primary Human Hepatocytes

This study develops a method to generate and expand hepatobiliary organoids from adult human hepatocytes, which retain liver function and can model liver diseases.

Tracer-based lipidomics identifies novel disease-specific biomarkers in mitochondrial β-oxidation disorders

The paper uses tracer-based lipidomics to identify two new disease-specific biomarkers for mitochondrial β-oxidation disorders, revealing insights into lipid metabolism and potential diagnostic applications.

Mutation-specific reporter for the optimization and enrichment of prime editing

This paper introduces a fluorescent reporter system for evaluating and enhancing prime editing efficiency in genomic targets.

Prime editing for functional repair in patient-derived disease models

This paper demonstrates the use of prime editing to correct genetic mutations in patient-derived organoids, showing high efficiency and precision with minimal off-target effects.