Author

James A.M. Hall

University of CambridgeORCID 0000-0002-8124-5434Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Aldo Segura‐CabreraiD· 1 shared Alexandra BeckiD· 1 shared Andrew R. LeachiD· 1 shared Andrew S. Barthorpe· 1 shared Ben S. SiddersiD· 1 shared Caitlin HalliD· 1 shared Carolin M. SaueriD· 1 shared Charlotte TolleyiD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperSystems Biology

Aldo Segura‐CabreraORCID

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2 papers

Recent·Most cited

Absolute copy number fitting from shallow whole genome sequencing data

Carolin M. Sauer, Matthew Eldridge, Maria Vias, James A.M. Hall, Samantha E. Boyle, Geoff Macintyre, Thomas Paul Bradley, Florian M. Markowetz, James D. Brenton

The paper evaluates tools for estimating absolute copy numbers from shallow whole genome sequencing data and introduces an improved tool called Rascal.

bioRxiv · Jul 19, 2021 · PreprintBioinformatics

Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens

Emanuel Gonçalves, Aldo Segura‐Cabrera, Clare Pacini, Gabriele Picco, Fiona M. Behan, Patricia Jaaks, Elizabeth A. Coker, Donny van der Meer, Andrew S. Barthorpe, Howard W. Lightfoot, Tatiana Mironenko, Alexandra Beck, Laura Richardson, Wanjuan Yang, Ermira Lleshi, , Mathew J. Garnett

This study integrates drug sensitivity data with CRISPR screens to identify drug mechanisms and biomarkers for cancer therapy.

Molecular Systems Biology · Jul 1, 2020Peer-reviewedSystems Biology