Author

Wayne O. Hemphill

Howard Hughes Medical InstituteORCID 0000-0002-8136-1574Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Thomas R. CechiD· 3 shared Anne R. GoodingiD· 1 shared Annette H. ErbseiD· 1 shared Arthur J. ZaugiD· 1 shared Cody J.S. HechtiD· 1 shared Deborah S. WuttkeiD· 1 shared Halley R. SteineriD· 1 shared Jackson R. Kominsky· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMolecular Biology

Thomas R. CechORCID

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3 papers

Recent·Most cited

Human vault RNAs exhibit diverse expression patterns and inter-locus compensation

Wayne O. Hemphill, Arthur J. Zaug, Cody J.S. Hecht, Thomas R. Cech

The paper examines the expression patterns and functional relationships of human vault RNA paralogs through knockout experiments in cell lines, suggesting potential functional connections but no clear biological roles.

RNA · Jul 30, 2026Peer-reviewedMolecular Biology

RNA-induced PRC2 inhibition depends on the sequence of bound RNA

Jiarui Song, Liqi Yao, Anne R. Gooding, Valentin Thron, Wayne O. Hemphill, Karen J. Goodrich, Annette H. Erbse, Vignesh Kasinath, Thomas R. Cech

This study shows that RNA sequence determines whether it inhibits PRC2 methyltransferase activity by dimerizing the complex or retains its activity by binding monomers.

Nature Communications · Apr 23, 2026Peer-reviewedBiochemistry

Transcription factors ERα and Sox2 have differing multiphasic DNA and RNA binding mechanisms

Wayne O. Hemphill, Halley R. Steiner, Jackson R. Kominsky, Deborah S. Wuttke, Thomas R. Cech

This study investigates the DNA and RNA binding kinetics of ERα and Sox2, revealing distinct multiphasic binding mechanisms with ER showing novel triphasic association behavior.

RNA · May 17, 2024Peer-reviewedBiophysics