Ran Zhou

The paper shows that 25-hydroxycholesterol disrupts brain endothelial function by altering cholesterol metabolism, linking viral infection to brain vessel dysfunction in intracerebral haemorrhage.

The paper introduces SCAPE-APA, an improved version of SCAPE for estimating alternative polyadenylation events from scRNA-seq data, with optimizations for speed and reliability.

PerturbAtlas re-analyzes 122,801 RNA-seq libraries to provide gene expression and splicing data from genetic perturbations across 13 species, enabling trend analysis and causal perturbation identification.

Sashimi.py provides a flexible and scalable tool for visualizing genomic data across multiple assays and formats, enabling combinatorial analysis of regulatory mechanisms.

The paper analyzes single-cell RNA data from human intracranial aneurysms to identify cell types and inflammation features associated with rupture.