25-hydroxycholesterol promotes brain endothelial dysfunction by remodelling cholesterol metabolism
Víctor S. Tapia, Sarah E. Withers, Ran Zhou, Abigail Bennington, Christopher Hoyle, Frances Hedley, Adam El Khouja, Nadim Luka, Marco Massimo, Siobhan Crilly, Katherine R. Long, Catherine B. Lawrence, Paul R. Kasher
The paper shows that 25-hydroxycholesterol disrupts brain endothelial function by altering cholesterol metabolism, linking viral infection to brain vessel dysfunction in intracerebral haemorrhage.
Disease Models & Mechanisms · May 23, 2025Peer-reviewedNeuroscience