Junli Gao

Single-cell transcriptomics and machine learning reveal RNF144B and C5AR1 as immune-related biomarkers and therapeutic targets in myocardial infarction

This paper identifies a 13-gene signature, including RNF144B and C5AR1, associated with myocardial infarction through transcriptomics and machine learning, highlighting their role in immune modulation and suggesting CCX168 as a therapeutic candidate.

Single-Cell Sequencing Identifies the Crucial Role of Mitochondrial Fission-Fusion Balance in Cardiac Hypertrophy Progression

The paper uses single-cell and bulk RNA sequencing to compare pathological and physiological cardiac hypertrophy, finding that mitochondrial fission genes drive pathological progression.

ADAM10 mediates macroglial cell fate decisions in the developing brain

The paper shows ADAM10 regulates macroglial cell fate by promoting astrocyte generation and inhibiting oligodendrocyte production in developing brains.