Wenzhi Sun

Dopamine Accumulation Dynamics Control Time Perception

The paper investigates how dopamine accumulation dynamics influence time perception in mice, finding that temporal accumulation rates, not absolute levels, determine time estimation.

rAAV-miniBEND: A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modeling

The paper develops a rAAV vector, rAAV-miniBEND, for specific gene delivery to brain endothelial cells and models cerebrovascular malformations like CCM and AVM.

Curved light sheet microscopy for centimeter-scale cleared tissues imaging

The paper introduces a curved light sheet microscope for high-throughput imaging of cleared tissues, achieving diffraction-limited resolution over a large field of view.

Inferring metabolite states from spatial transcriptomes using multiple graph neural network

This paper introduces MGFEA, a method to infer metabolite states from spatial transcriptomes and improve accuracy using multi-omics data.

The subcommissural organ regulates brain development via secreted peptides

The paper identifies three genes highly expressed in the subcommissural organ (SCO) and shows their ablation causes brain developmental defects, with peptide reintroduction rescuing these defects.

ADAM10 mediates macroglial cell fate decisions in the developing brain

The paper shows ADAM10 regulates macroglial cell fate by promoting astrocyte generation and inhibiting oligodendrocyte production in developing brains.

The Neural Basis of Delayed Gratification

This study trains mice to perform a delayed gratification task and shows that VTA dopamine neuron activity increases during waiting, with reinforcement learning modeling supporting the role of sustained dopaminergic signals in delaying gratification.

Piezo2 mediates ultrasonic hearing via cochlear outer hair cells in mice

This study shows that Piezo2 in outer hair cells is essential for ultrasonic hearing in mice, but not for low-frequency hearing.

A distinct population of L6 neurons in mouse V1 mediate cross-callosal communication

The paper identifies a distinct population of L6 neurons in mouse V1 that mediate cross-callosal communication through anatomical and functional analysis.

Precision mapping of the mouse brain metabolome

This study maps the mouse brain metabolome using targeted metabolomics, creating detailed maps of 79 metabolites at high resolution.

Template-independent genome editing and repairing correct frameshift disease in vivo

This study demonstrates that NHEJ-mediated frame restoration can efficiently correct frameshift mutations in vivo, restoring function in a mouse model of Usher syndrome.

Video-rate volumetric functional imaging of the brain at synaptic resolution

This paper introduces a method to achieve video-rate volumetric imaging of brain activity at synaptic resolution using Bessel foci in two-photon microscopy.