Émilie Brasset

This study identifies His2Av as a critical histone variant that regulates piRNA pathway activation and prevents genome instability during oogenesis in Drosophila.

This study identifies Traffic jam as a master regulator of the somatic piRNA pathway in Drosophila ovaries, showing its role in controlling piRNA factors and the flamenco cluster.

The paper identifies a dual histone modification (H3K9me3 and H3K27me3) that specifies Rhino binding to a subset of piRNA source loci in Drosophila germ cells, independent of Kipferl.

The paper shows that gap junctions and amino acid import in somatic cells support germ cell growth in Drosophila by enabling metabolic transfer and regulating translation.

The paper identifies KDM3 as a histone demethylase that prevents auto-immune piRNA production from gene-containing regions in Drosophila by inhibiting piRNA cluster formation.

This study reactivates an errantivirus in Drosophila somatic cells, showing it can invade oocytes and trigger a germline immune response.

The paper identifies conserved small nucleotide sequences that drive piRNA biogenesis from genes and lncRNAs, revealing a new regulatory pathway in insect and mammalian species.

The paper shows that trapping a somatic endogenous retrovirus into a germline piRNA cluster silences it in germ cells, protecting the germline from further invasion.

This paper shows that high temperature can induce a stable epigenetic conversion of a transgene cluster into an active piRNA-producing locus in flies, without maternal piRNA inheritance.