Author

Miguel Martinez-Ara

The Netherlands Cancer InstituteORCID 0000-0002-8219-0754Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2

Frequent Co-Authors

Bas van SteenseliD· 3 shared Federico ComoglioiD· 2 shared Christ LeemansiD· 1 shared Elzo de WitiD· 1 shared Hans Teunissen· 1 shared J. Omar Yáñez-CunaiD· 1 shared Joris van ArensbergeniD· 1 shared Koen RademakeriD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMolecular Biology

Bas van SteenselORCID

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3 papers

Recent·Most cited

Genome - nuclear lamina interactions are multivalent and cooperative

Lise Dauban, M Eder, Marcel de Haas, Vinícius H. Franceschini-Santos, J. Omar Yáñez-Cuna, Moreno Martinovic, Tom van Schaik, Christ Leemans, Hans Teunissen, Koen Rademaker, Miguel Martinez-Ara, Martijn Verkuilen, Elzo de Wit, Bas van Steensel

The paper investigates how genomic regions called LADs interact with the nuclear lamina, finding that these interactions are multivalent and cooperative, with some subregions having stronger affinity and influencing neighboring sequences.

Nature Structural & Molecular Biology · Sep 1, 2025Peer-reviewedMolecular Biology

Large-scale analysis of the integration of enhancer-enhancer signals by promoters

Miguel Martinez-Ara, Federico Comoglio, Bas van Steensel

The paper tests how enhancer pairs combine to activate promoters in mouse cells, finding near-additive behavior with non-linear scaling depending on promoter strength.

eLife · Oct 28, 2024Peer-reviewedSystems Biology

Systematic analysis of intrinsic enhancer-promoter compatibility in the mouse genome.

Miguel Martinez-Ara, Federico Comoglio, Joris van Arensbergen, Bas van Steensel

The paper systematically analyzes enhancer-promoter compatibility in the mouse genome using high-throughput assays, finding significant promoter selectivity and diverse compatibility patterns.

Molecular Cell · Apr 29, 2022Peer-reviewedGenetics