M Eder

This study identifies factors influencing Sleeping Beauty transposition, showing chromatin context, cargo size, and transcriptional activity affect efficiency and reintegration patterns.

The paper investigates how CTCF binding sites affect the regulatory landscape of the mouse Sox2 locus by relocating them and measuring their impact on gene expression.

The paper relocates promoter-reporter constructs to study the positional relationship between the Sox2 gene and its enhancer, revealing gene-mediated confinement of enhancer activity.

The paper investigates how genomic regions called LADs interact with the nuclear lamina, finding that these interactions are multivalent and cooperative, with some subregions having stronger affinity and influencing neighboring sequences.

The paper quantifies how enhancer-promoter interactions influence transcription through nonlinear relationships and reveals mechanisms of transcriptional control via chromosome structure.