Moreno Martinovic

This study shows CTCF has dual roles in early mammalian development: promoting morphogenesis through promoter binding early on and enabling correct development via looping later.

The paper investigates how genomic regions called LADs interact with the nuclear lamina, finding that these interactions are multivalent and cooperative, with some subregions having stronger affinity and influencing neighboring sequences.

This study shows that cohesin is not always necessary for enhancer function, as some enhancers can act independently through synergy or insulators.