Author

Suraj Upadhya

Broad InstituteORCID 0000-0002-8242-3052Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:ATAC-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Anna J. Nathanson· 1 shared Bernadette O’DonovaniD· 1 shared Boris KantoriD· 1 shared Dana Silvian· 1 shared Dellila Hodgson· 1 shared Eric F. ZaniewskiiD· 1 shared Jenny A. KleiniD· 1 shared Joseph E. RittineriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Anna J. Nathanson

Mutual co-authors in cluster

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintJun 3, 2026

Aberrant chromatin remodeling influences human neural cell fate change in Trisomy 21

Jenny A. Klein, Suraj Upadhya, Anna J. Nathanson…·Lindy E. Barrett

This study identifies aberrant chromatin remodeling in Trisomy 21 NPCs that impairs neurogenesis and shows that PRC2 inhibition can partially restore neurogenic potential.

DOI 10.64898/2026.06.01.729170

humanscRNA-seq

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NeurosciencebioRxivPreprintJun 16, 2025

SNCA-targeted epigenome therapy for Parkinsons disease alleviates pathological and behavioral perturbations in a mouse model

Bernadette O’Donovan, Joseph E. Rittiner, Suraj Upadhya…·Ornit Chiba‐Falek

This study demonstrates that SNCA-targeted epigenome therapy reduces α-synuclein expression, aggregation, and motor deficits in a PD mouse model.

DOI 10.1101/2025.06.16.659948

mouseexperimental assay

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