Author

Anna J. Nathanson

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jenny A. KleiniD· 3 shared Lindy E. BarrettiD· 3 shared Darina TrendafilovaiD· 2 shared Lee L. RubiniD· 2 shared Martin H. BerryeriD· 2 shared Angelica MessanaiD· 1 shared Anne Elizabeth CarpenteriD· 1 shared Beth A. CiminiiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersNeuroscience

Jenny A. KleinORCID

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Author profile →

3 papers

Recent·Most cited

Aberrant chromatin remodeling influences human neural cell fate change in Trisomy 21

Jenny A. Klein, Suraj Upadhya, Anna J. Nathanson, Dana Silvian, Eric F. Zaniewski, Robert Morris, Wilhelm Haas, Lindy E. Barrett

This study identifies aberrant chromatin remodeling in Trisomy 21 NPCs that impairs neurogenesis and shows that PRC2 inhibition can partially restore neurogenic potential.

bioRxiv · Jun 3, 2026 · PreprintNeuroscience

Robust induction of functional astrocytes using NGN2 expression in human pluripotent stem cells

Martin H. Berryer, Matthew Tegtmeyer, Loïc Binan, Vera Valakh, Anna J. Nathanson, Darina Trendafilova, Ethan Crouse, Jenny A. Klein, Daniel Meyer, Olli P. H. Pietiläinen, Francesca A. Rapino, Samouil L. Farhi, Lee L. Rubin, Steven A. McCarroll, Ralda Nehme, Lindy E. Barrett

This study develops a rapid, scalable method to generate functional human astrocytes from pluripotent stem cells using NGN2 induction, showing high homogeneity and disease relevance.

iScience · May 30, 2023Peer-reviewedNeuroscience

An automated high-content synaptic phenotyping platform in human neurons and astrocytes reveals a role for BET proteins in synapse assembly

Martin H. Berryer, Gizem Rizki, Anna J. Nathanson, Jenny A. Klein, Darina Trendafilova, Sara G. Susco, Daisy Lam, Angelica Messana, Kristina M. Holton, Kyle W. Karhohs, Beth A. Cimini, Kathleen Lindahl Pfaff, Anne Elizabeth Carpenter, Lee L. Rubin, Lindy E. Barrett

The paper develops an automated high-content synaptic phenotyping platform in human neurons and astrocytes, identifying BET inhibitors as key regulators of synapse assembly.

eLife · Apr 12, 2023Peer-reviewedNeuroscience